Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 4/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.33 |
| ▸ | TNNI3K | Q59H18 | 4/20 | 0.33 |
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28451635 | 0.72 | CYP1A2 (0.52) | KMT2ATRPV1KDRMAPK14TNNI3K | |
| SCHEMBL1936666 | 0.71 | ALDH1A1 (0.39) | MAPK1PKMKMT2ALMNAKDR | |
| Hydrochloric Acid SCHEMBL28447698 | 0.71 | CYP1A2 (0.51) | KMT2ATRPV1KDRMAPK14TNNI3K | |
| SCHEMBL18018332 | 0.70 | CACNA1H (0.43) | POLBGAA | |
| SCHEMBL18047666 | 0.69 | KCNH2 (0.38) | MAPK1POLBKMT2ALMNAGAA | |
| SCHEMBL22582959 | 0.68 | MAPK1 (0.43) | MAPK1POLBPKMKMT2AGAA | |
| SCHEMBL22583410 | 0.68 | MAPK1 (0.49) | MAPK1POLBPKMKMT2ALMNA | |
| SCHEMBL18047664 | 0.68 | TRPA1 (0.40) | AGBL2 | |
| SCHEMBL16161634 | 0.67 | KMO (0.54) | PKMLMNAMAPT | |
| SCHEMBL28442827 | 0.63 | MAPT (0.34) | POLBPKMKDRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109476640-B | Bicyclic proline compounds | 豪夫迈·罗氏有限公司 | 2022-02-25 | — | — | CN | disclosed |
| CN-107922392-B | 1- (hetero) arylsulfonyl- (pyrrolidine or piperidine) -2-carboxamide derivatives and uses thereof | 豪夫迈·罗氏有限公司 | 2020-07-21 | — | — | CN | disclosed |