Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 8/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.42 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28453156 | 0.86 | OPRM1 (0.44) | OPRM1OPRD1OPRK1KDM4EALDH1A1 | |
| SCHEMBL28121772 | 0.83 | POLB (0.50) | OPRM1OPRD1OPRK1KDM4EALDH1A1 | |
| SCHEMBL10224798 | 0.79 | KDM4E (0.55) | KDM4ECYP1A2CYP2C19 | |
| SCHEMBL392452 | 0.77 | GLA (0.58) | OPRM1OPRD1OPRK1SLC26A6KDM4E | |
| SCHEMBL8440801 | 0.76 | CTSS (0.52) | OPRM1OPRD1OPRK1ALDH1A1CTSS | |
| SCHEMBL28121189 | 0.75 | MTNR1A (0.50) | OPRM1OPRD1OPRK1KDM4EALDH1A1 | |
| SCHEMBL7516052 | 0.75 | KDM4E (0.56) | OPRM1OPRD1OPRK1KDM4EALDH1A1 | |
| SCHEMBL3650795 | 0.73 | OPRM1 (0.51) | OPRM1OPRD1OPRK1KDM4EALDH1A1 | |
| SCHEMBL28121194 | 0.73 | HPGD (0.59) | OPRM1OPRD1OPRK1ALDH1A1HPGD | |
| SCHEMBL3300893 | 0.71 | SPR (0.56) | OPRM1OPRD1OPRK1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107922430-B | 2-substituted benzimidazole-4-formamide compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2020-09-04 | — | — | CN | disclosed |