Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5504188 | 1.00 | REN (0.63) | RENCYP3A4 | |
| SCHEMBL1859127 | 0.90 | REN (0.59) | RENCYP3A4 | |
| SCHEMBL13250137 | 0.90 | REN (0.59) | RENCYP3A4 | |
| SCHEMBL1859124 | 0.90 | REN (0.59) | RENCYP3A4 | |
| SCHEMBL4754618 | 0.89 | REN (0.69) | RENCYP3A4 | |
| SCHEMBL4295605 | 0.88 | REN (0.61) | RENCYP3A4 | |
| SCHEMBL4295601 | 0.88 | REN (0.61) | RENCYP3A4 | |
| SCHEMBL4301567 | 0.88 | REN (0.61) | RENCYP3A4 | |
| SCHEMBL4305939 | 0.87 | REN (0.74) | RENCYP3A4 | |
| SCHEMBL4298251 | 0.87 | REN (0.74) | RENCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100317697-A1 | Renin Inhibitors | VITAE PHARMACEUTICALS, INC. | 2010-12-16 | — | — | US | disclosed |
| US-20100280005-A1 | Renin Inhibitors | VITAE PHARMACEUTICALS, INC. | 2010-11-04 | — | — | US | disclosed |
| US-20100179109-A1 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. | 2010-07-15 | — | — | US | disclosed |
| US-20100130471-A1 | Renin Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2010-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179109-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | REN 1/4885CYP3A4 2462/4885 |
| US-20100280005-A1 | Renin Inhibitors | REN, ACE, AGTR1 | REN 1/4885CYP3A4 2618/4885 |
| US-20100317697-A1 | Renin Inhibitors | REN, ACE, SERPINB1 | REN 1/4885CYP3A4 2575/4885 |
| US-20100130471-A1 | Renin Inhibitors | ACE, REN, DNPEP | REN 2/4885CYP3A4 3137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.