SCHEMBL28458232

SCHEMBL28458232

CN(c1ccc(Cl)cc1)C(C#N)C#N

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.38
ALDH1A1 P00352 7/20 0.37
KDM4E B2RXH2 1/20 0.37
HPGD P15428 1/20 0.37
ALOX15 P16050 1/20 0.37
HSD17B10 Q99714 1/20 0.37
SLC6A2 P23975 2/20 0.36
SLC6A4 P31645 2/20 0.36
TDP1 Q9NUW8 2/20 0.34
POLB P06746 1/20 0.34
SRC P12931 1/20 0.34
LMNA P02545 1/20 0.33
CYP2A6 P11509 1/20 0.33
CES1 P23141 1/20 0.33
CHKA P35790 2/20 0.33
L3MBTL1 Q9Y468 1/20 0.32
AOC3 Q16853 1/20 0.32
PYCR1 P32322 1/20 0.32
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28648701 0.81 ALDH1A1 (0.46) GAAALDH1A1KDM4EALOX15HSD17B10
SCHEMBL28636212 0.79 APP (0.39) GAAALDH1A1KDM4EHPGDSLC6A2
SCHEMBL28650477 0.79 PYCR1 (0.33) ALDH1A1KDM4EPOLBSRCLMNA
SCHEMBL28640840 0.78 MEN1 (0.38) GAAALDH1A1SLC6A2SLC6A4POLB
SCHEMBL28471408 0.76 SLC2A1 (0.47) GAAALDH1A1KDM4EHPGDHSD17B10
SCHEMBL5301480 0.73 ALDH1A1 (0.47) ALDH1A1KDM4EHPGDALOX15HSD17B10
SCHEMBL28651522 0.71 PYCR1 (0.47) GAAALDH1A1KDM4ESLC6A2POLB
SCHEMBL28748357 0.69 LMNA (0.47) ALDH1A1KDM4EHPGDALOX15HSD17B10
SCHEMBL28648629 0.68 SLC6A2 (0.41) ALDH1A1KDM4EHPGDHSD17B10SLC6A2
SCHEMBL20893275 0.67 CHRNB2 (0.41) ALDH1A1KDM4EHPGDALOX15HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113444031-B Synthesis method of 2, 2-diaryl acetonitrile compound 兰州大学 2023-03-03 CN disclosed
CN-111620792-B Synthesis method of N, N-disubstituted cyano formamide 兰州大学 2023-01-03 CN disclosed
CN-113683550-A Synthesis method of N- (cyano (2-cyano substituted phenyl) methyl) substituted tertiary amine 兰州大学 2021-11-23 CN disclosed
CN-113444031-A Synthetic method of 2, 2-diaryl acetonitrile compound 兰州大学 2021-09-28 CN disclosed
CN-111620792-A Synthesis method of N, N-disubstituted cyano formamide 兰州大学 2020-09-04 CN disclosed