Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.50 |
| ▸ | SRC | P12931 | 2/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | ABL2 | P42684 | 1/20 | 0.50 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28458581 | 0.92 | SRC (0.47) | EGFRSRCABL1ABL2USP30 | |
| SCHEMBL28460213 | 0.89 | USP30 (0.45) | EGFRSRCABL1ABL2USP30 | |
| SCHEMBL28452589 | 0.89 | USP30 (0.45) | EGFRSRCABL1ABL2USP30 | |
| SCHEMBL28458345 | 0.86 | BTK (0.45) | EGFRSRCABL1ABL2USP30 | |
| SCHEMBL28458448 | 0.86 | GPR119 (0.48) | ABL1USP30FGFR3KDRCHEK2 | |
| SCHEMBL28898133 | 0.86 | APLNR (0.44) | EGFRSRCABL1ABL2USP30 | |
| SCHEMBL29968466 | 0.86 | GPR119 (0.48) | ABL1USP30FGFR3KDRCHEK2 | |
| SCHEMBL28449733 | 0.86 | CNR1 (0.46) | USP30MEN1KMT2ACHEK2BTK | |
| SCHEMBL28461486 | 0.86 | GPR119 (0.46) | USP30FGFR3KDRCHEK2 | |
| SCHEMBL28898963 | 0.86 | HDAC1 (0.46) | USP30FGFR3KDRCHEK2IRAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111662232-B | Small molecule compound with 2H-indazole structure and synthesis and application thereof | 中国科学院上海药物研究所 | 2022-08-02 | — | — | CN | disclosed |
| CN-111662232-A | Small molecule compound with 2H-indazole structure and synthesis and application thereof | 中国科学院上海药物研究所 | 2020-09-15 | — | — | CN | disclosed |