SCHEMBL28459879

SCHEMBL28459879

CS(=O)(=O)n1cc(-c2ccc(F)cc2)nn1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 12/20 0.57
PTGS1 P23219 5/20 0.57
CA1 P00915 3/20 0.50
CA2 P00918 3/20 0.50
CA5A P35218 2/20 0.50
CA5B Q9Y2D0 2/20 0.50
MAPK1 P28482 1/20 0.41
CA12 O43570 1/20 0.41
CA9 Q16790 1/20 0.41
STS P08842 1/20 0.40
CHRNB2 P17787 3/20 0.40
CHRNB4 P30926 3/20 0.40
CHRNA3 P32297 3/20 0.40
CHRNA7 P36544 3/20 0.40
CHRNA4 P43681 3/20 0.40
KDM4E B2RXH2 1/20 0.39
MITF O75030 1/20 0.39
ALDH1A1 P00352 1/20 0.39
LMNA P02545 1/20 0.39
STAT3 P40763 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28230416 0.85 PTGS2 (0.56) PTGS2PTGS1CA1CA2CA5A
SCHEMBL28229596 0.83 PTGS2 (0.41) PTGS2PTGS1CA1CA2CA5A
SCHEMBL28451943 0.83 PTGS2 (0.57) PTGS2PTGS1CA1CA2CA5A
SCHEMBL31469512 0.83 PTGS2 (0.52) PTGS2PTGS1CA1CA2CA5A
SCHEMBL28229563 0.83 PTGS2 (0.55) PTGS2PTGS1CA1CA2CA5A
SCHEMBL28579525 0.83 PTGS2 (0.60) PTGS2PTGS1CA12CA9LMNA
SCHEMBL31469553 0.81 CHRNB2 (0.44) PTGS2PTGS1CA1CA2CA5A
SCHEMBL29009134 0.81 PTGS2 (0.42) PTGS2PTGS1CA1CA2CA12
SCHEMBL29009126 0.81 NR1H4 (0.50) PTGS2PTGS1CA1CA2CA12
SCHEMBL28229558 0.81 PTGS2 (0.59) PTGS2PTGS1CA1CA2CA5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108218917-B Preparation method of (1-aminovinyl) phosphine oxide derivative 广西大学 2020-08-18 CN claimed
CN-108218917-A A kind of (1- amine vinyls) phosphine oxygen derivative and preparation method thereof 广西大学 2018-06-29 CN claimed
CN-119490463-A Beta-triazole derivative and synthetic method and application thereof 华东师范大学 2025-02-21 CN disclosed
CN-112125891-B N2Selective tetrahydrofuran/tetrahydrothiophene substituted triazole derivative and synthesis method and application thereof 华东师范大学 2022-06-07 CN disclosed
CN-112125891-A N2Selective tetrahydrofuran/tetrahydrothiophene substituted triazole derivative and synthesis method and application thereof 华东师范大学 2020-12-25 CN disclosed
CN-108218917-B Preparation method of (1-aminovinyl) phosphine oxide derivative 广西大学 2020-08-18 CN disclosed
CN-108218917-A A kind of (1- amine vinyls) phosphine oxygen derivative and preparation method thereof 广西大学 2018-06-29 CN disclosed