Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MYC | P01106 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8024016 | 0.83 | ALDH1A1 (0.64) | ALDH1A1KDM4EHPGDHSD17B10MAPK1 | |
| SCHEMBL28456544 | 0.81 | ALDH1A1 (0.62) | ALDH1A1KDM4EHPGDHSD17B10MAPK1 | |
| SCHEMBL1989131 | 0.81 | ALDH1A1 (0.62) | ALDH1A1KDM4EHPGDHSD17B10MAPK1 | |
| SCHEMBL20509554 | 0.80 | ALDH1A1 (0.60) | ALDH1A1KDM4EHPGDHSD17B10MAPK1 | |
| SCHEMBL29263206 | 0.79 | PTPN1 (0.59) | ALDH1A1KDM4EHPGDHSD17B10MAPK1 | |
| SCHEMBL383490 | 0.79 | ALDH1A1 (0.58) | ALDH1A1KDM4EHPGDHSD17B10MAPK1 | |
| SCHEMBL13951454 | 0.79 | ALDH1A1 (0.58) | ALDH1A1KDM4EHPGDHSD17B10MAPK1 | |
| SCHEMBL382128 | 0.77 | KDM4E (0.57) | ALDH1A1KDM4EHPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL28602270 | 0.77 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDHSD17B10MAPK1 | |
| SCHEMBL29057024 | 0.77 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDHSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112312909-A | Compounds for the treatment of kinase-dependent disorders | 埃克塞里艾克西斯公司 | 2021-02-02 | — | — | CN | disclosed |
| CN-111936487-A | Compounds for the treatment of kinase-dependent disorders | 埃克塞里艾克西斯公司 | 2020-11-13 | — | — | CN | disclosed |
| CN-111757735-A | Compounds for the treatment of kinase-dependent disorders | 埃克塞里艾克西斯公司 | 2020-10-09 | — | — | CN | disclosed |
| CN-111698987-A | Halogenated derivatives of morphinans and uses thereof | 萨鲁德医疗公司 | 2020-09-22 | — | — | CN | disclosed |