Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 4/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16528528 | 0.86 | HSD17B10 (0.38) | HSD17B10SMN1; SMN2POLBL3MBTL1LMNA | |
| SCHEMBL25193443 | 0.86 | HSD17B10 (0.38) | HSD17B10SMN1; SMN2POLBL3MBTL1LMNA | |
| SCHEMBL31296240 | 0.86 | HSD17B10 (0.38) | HSD17B10SMN1; SMN2POLBL3MBTL1LMNA | |
| SCHEMBL28473523 | 0.79 | POLB (0.38) | POLBL3MBTL1KCNH2HRH3 | |
| SCHEMBL34473181 | 0.77 | HSD17B10 (0.47) | HSD17B10ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL21996681 | 0.77 | GPR119 (0.41) | — | |
| SCHEMBL25180826 | 0.76 | SIGMAR1 (0.49) | — | |
| SCHEMBL30511049 | 0.76 | KLK7 (0.47) | ATM | |
| SCHEMBL27374399 | 0.75 | HTR2C (0.37) | HTR2CSLC6A4ALDH1A1HTR2A | |
| SCHEMBL29286314 | 0.73 | CA14 (0.35) | HSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111801100-B | 7-substituted sulfoimidoyl purinone compounds and derivatives for the treatment and prevention of liver cancer | 豪夫迈·罗氏有限公司 | 2023-10-24 | — | — | CN | disclosed |
| CN-111801100-A | 7-substituted sulfoxy-purinone compounds and derivatives for the treatment and prevention of liver cancer | 豪夫迈·罗氏有限公司 | 2020-10-20 | — | — | CN | disclosed |