Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2841416 | 0.99 | HTR1A (0.49) | CYP1A2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL2844641 | 0.96 | CYP1A2 (0.49) | CYP1A2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL5210378 | 0.81 | CYP1A2 (0.51) | CYP1A2ADRA1ALOXL2 | |
| SCHEMBL2937018 | 0.80 | CYP1A2 (0.54) | CYP1A2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL19563522 | 0.80 | CYP3A4 (0.49) | DRD2 | |
| SCHEMBL2415094 | 0.80 | LOXL2 (0.40) | CYP1A2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL20562641 | 0.79 | CASP1 (0.53) | CASP1NSD2MTNR1AMTNR1B | |
| SCHEMBL7829170 | 0.79 | MAPT (0.51) | CYP1A2LOXL2 | |
| SCHEMBL7832661 | 0.79 | MAPT (0.51) | CYP1A2LOXL2 | |
| SCHEMBL2333461 | 0.79 | LOXL2 (0.62) | CYP1A2HTR1AADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251324-A1 | HETEROARYL-ALKYLCARBAMATE COMPOUNDS AND THEIR USE AS INHIBITORS OF THE FAAH ENZYME | Sanofi-Aventis (FR) | 2010-11-17 | — | — | EP | disclosed |
| EP-1720829-B1 | DERIVATIVES OF HETEROARYL-ALKYLCARBAMATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | SANOFI AVENTIS (FR) | 2009-10-14 | — | — | EP | disclosed |