⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL476497 | 0.75 | — | — | |
| SCHEMBL28419828 | 0.73 | ALDH1A1 (0.38) | — | |
| SCHEMBL22863851 | 0.73 | ALDH1A1 (0.33) | — | |
| SCHEMBL1685072 | 0.73 | ALDH1A1 (0.33) | — | |
| SCHEMBL1685071 | 0.73 | ALDH1A1 (0.33) | — | |
| SCHEMBL22972244 | 0.73 | — | — | |
| SCHEMBL11453119 | 0.73 | DGAT1 (0.34) | — | |
| SCHEMBL11129569 | 0.71 | — | — | |
| SCHEMBL1449319 | 0.71 | — | — | |
| SCHEMBL626444 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250145629-A1 | ION CHANNEL MODULATORS | PRAXIS PRECISION MEDICINES, INC. | 2025-05-08 | — | — | US | disclosed |
| US-12145939-B2 | Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators | PRAXIS PRECISION MEDICINES, INC. (US) | 2024-11-19 | — | — | US | disclosed |
| US-20240043433-A1 | ION CHANNEL MODULATORS | PRAXIS PRECISION MEDICINES, INC. | 2024-02-08 | — | — | US | disclosed |
| EP-3601284-B1 | NAPHTHYRIDINES AS INHIBITORS OF HPK1 | HOFFMANN LA ROCHE (CH) | 2023-12-27 | — | — | EP | disclosed |
| US-11767325-B2 | Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-09-26 | — | — | US | disclosed |
| US-11767325-B2 | Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-09-26 | — | — | US | disclosed |
| CN-110678466-B | Diazanaphthalenes as HPK1 inhibitors | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | disclosed |
| WO-2022072634-A1 | BICYCLIC COMPOUNDS FOR USE IN THE TREATMENT CANCER | SCORPION THERAPEUTICS, INC. (US) | 2022-04-07 | — | — | WO | disclosed |
| US-11034692-B1 | Naphthyridines as inhibitors of HPK1 | GENENTECH, INC. (US) | 2021-06-15 | — | — | US | disclosed |
| US-11034692-B1 | Naphthyridines as inhibitors of HPK1 | GENENTECH, INC. (US) | 2021-06-15 | — | — | US | disclosed |
| US-5731318-A | NEUROLOGICAL DISORDERS | BOEHRINGER INGELHEIM KG (DE) | 1998-03-24 | — | — | US | disclosed |
| US-5607941-A | BENZOMORPHAN DERIVATIVES | BOEHRINGER INGELHEIM KG (DE) | 1997-03-04 | — | — | US | disclosed |
| US-4969950-A | Triazole compounds and methods for regulating plant growth | BASF AKTIENGESELLSCHAFT (DE) | 1990-11-13 | — | — | US | disclosed |
| EP-0291852-A1 | Triazole compounds, process for their preparation and method for plant growth regulation | BASF Aktiengesellschaft (DE) | 1988-11-23 | — | — | EP | disclosed |
| EP-0006449-B1 | 2-(2-ALKOXYETHYL)-2'-HYDROXY-6.7-BENZOMORPHANE DERIVATIVES, THEIR ACID ADDITION SALTS, MEDICAMENTS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION | C.H. BOEHRINGER SOHN (DE) | 1982-12-08 | — | — | EP | disclosed |
| US-4293556-A | Analgesic 2-(2-alkoxy-ethyl)-2'-hydroxy-6,7-benzomorphans and salts thereof | BOEHRINGER INGELHEIM GMBH (DE) | 1981-10-06 | — | — | US | disclosed |
| EP-0006449-A1 | 2-(2-Alkoxyethyl)-2'-hydroxy-6.7-benzomorphane derivatives, their acid addition salts, medicaments containing them and process for their preparation | C.H. BOEHRINGER SOHN (DE) | 1980-01-09 | — | — | EP | disclosed |
| US-4129704-A | Polymerization of vinyl monomers employing a diperoxyester mixture composition prepared by reacting dihydroperoxide and peroxyester forming carbonyl compounds | PENNWALT CORPORATION (US) | 1978-12-12 | — | — | US | disclosed |
| US-4097408-A | FROM DIHYDOPEROXIDE AND CARBONYL COMPOUND, POLYMERIZATION CATALYSTS | PENNWALT CORPORATION (US) | 1978-06-27 | — | — | US | disclosed |
| US-4015012-A | ANTHELMINTICS | BAYER AKTIENGESELLSCHAFT (DT) | 1977-03-29 | — | — | US | disclosed |