SCHEMBL28468675

SCHEMBL28468675

C=C(C)COC(=O)C(=[N+]=[N-])c1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.42
MAPT P10636 1/20 0.42
CYP1A2 P05177 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
ELANE P08246 1/20 0.38
GPR174 Q9BXC1 1/20 0.38
EGFR P00533 2/20 0.37
MAPK1 P28482 1/20 0.37
HIF1A Q16665 1/20 0.37
LMNA P02545 1/20 0.36
NPC1 O15118 2/20 0.35
RAB9A P51151 2/20 0.35
CES2 O00748 1/20 0.34
CES1 P23141 1/20 0.34
TSHR P16473 2/20 0.34
TDP1 Q9NUW8 1/20 0.34
PRSS1 P07477 1/20 0.34
CTSG P08311 1/20 0.34
CTRB1 P17538 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26091025 0.84 TDP1 (0.45) ALDH1A1MAPTCYP1A2CYP2C9CYP2C19
SCHEMBL900466 0.81 ALDH1A1 (0.54) ALDH1A1MAPTLMNANPC1RAB9A
SCHEMBL29557122 0.80 TDP1 (0.44) ALDH1A1MAPTCYP1A2CYP2C9CYP2C19
SCHEMBL28808083 0.78 LMNA (0.57) ALDH1A1MAPTCYP1A2CYP2C9CYP2C19
SCHEMBL2118322 0.78 MMP1 (0.40) ALDH1A1MAPTCYP1A2CYP2C9CYP2C19
SCHEMBL15977365 0.77 CYP3A4 (0.47) ALDH1A1MAPTCYP1A2CYP2C9CYP2C19
SCHEMBL16401664 0.76 TDP1 (0.56) ALDH1A1MAPTMAPK1LMNANPC1
SCHEMBL7575766 0.76 ELANE (0.38) ALDH1A1MAPTCYP1A2CYP2C9CYP2C19
SCHEMBL32681167 0.75 ELANE (0.36) ALDH1A1MAPTCYP1A2CYP2C9CYP2C19
SCHEMBL6354305 0.75 RAB9A (0.57) ALDH1A1CYP1A2CYP2C9CYP2C19MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111808003-A Preparation method of thioether 甘肃农业大学 2020-10-23 CN claimed
CN-111808003-A Preparation method of thioether 甘肃农业大学 2020-10-23 CN disclosed