SCHEMBL28469895

SCHEMBL28469895

C#CCC#Cc1ccc(F)cc1

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 1/20 0.38
HTT P42858 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
PYCR1 P32322 2/20 0.36
LMNA P02545 2/20 0.36
GRM5 P41594 2/20 0.34
KDM4E B2RXH2 2/20 0.34
MAOA P21397 1/20 0.34
MAOB P27338 1/20 0.34
DRD2 P14416 2/20 0.34
GRIN2B Q13224 1/20 0.34
TP53 P04637 1/20 0.33
HAO1 Q9UJM8 1/20 0.33
CHRM2 P08172 1/20 0.33
CHRM1 P11229 1/20 0.33
HCAR2 Q8TDS4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL102520 0.81 DRD2 (0.38) FFAR1HTTL3MBTL1PYCR1LMNA
SCHEMBL17971132 0.78 PYCR1 (0.38) HTTL3MBTL1PYCR1LMNAKDM4E
SCHEMBL6766702 0.77 CYP1A2 (0.54) FFAR1HTTLMNAKDM4E
SCHEMBL103643 0.77 MMP2 (0.47) FFAR1L3MBTL1LMNAGRM5KDM4E
SCHEMBL6766703 0.77 CYP1A2 (0.54) FFAR1HTTLMNAKDM4E
SCHEMBL7573145 0.73 CYP2C19 (0.60) FFAR1GRM5MAOBDRD2GRIN2B
SCHEMBL14575100 0.73 GABRP (0.41) FFAR1LMNAGRM5DRD2GRIN2B
SCHEMBL104471 0.73 FFAR1 (0.40) FFAR1LMNAGRM5MAOAMAOB
SCHEMBL7717366 0.72 GRM5 (0.50) FFAR1GRM5KDM4ETP53HAO1
SCHEMBL10300106 0.72 GRM5 (0.50) FFAR1GRM5KDM4ETP53HAO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111662147-B Process for preparing diynes and analogues thereof 清华大学 2021-08-10 CN disclosed
CN-111662147-A Process for preparing diynes and analogues thereof 清华大学 2020-09-15 CN disclosed