Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | TP53 | P04637 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30148069 | 1.00 | MAPKAPK2 (0.51) | MAPKAPK2MAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL28471570 | 0.88 | LMNA (0.51) | MAPTSMN1; SMN2ALDH1A1ABCG2KDM4E | |
| SCHEMBL28470332 | 0.85 | MAPKAPK2 (0.49) | MAPKAPK2MAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL30148042 | 0.85 | MAPKAPK2 (0.49) | MAPKAPK2MAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL9401140 | 0.79 | MAPKAPK2 (0.61) | MAPKAPK2MAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL30148066 | 0.78 | HDAC6 (0.37) | MAPKAPK2ALDH1A1 | |
| SCHEMBL28464318 | 0.78 | HDAC6 (0.37) | MAPKAPK2ALDH1A1 | |
| SCHEMBL28464365 | 0.77 | AKR1B10 (0.45) | ALDH1A1 | |
| SCHEMBL2707877 | 0.76 | MAPKAPK2 (0.62) | MAPKAPK2MAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL30148138 | 0.76 | MAPKAPK2 (0.47) | MAPKAPK2MAPTTP53ALDH1A1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111675725-B | Tetrahydro-beta-carbaline dimer and preparation method and application thereof | 中国药科大学 | 2023-01-24 | — | — | CN | disclosed |
| CN-111675725-A | Tetrahydro-beta-carbaline dimer and preparation method and application thereof | 中国药科大学 | 2020-09-18 | — | — | CN | disclosed |