Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 2/20 | 0.34 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2847118 | 1.00 | ACKR3 (0.36) | ACKR3TOP2AABCC2SMYD3CNR1 | |
| SCHEMBL13173537 | 0.93 | ACKR3 (0.36) | ACKR3TOP2AABCC2SMYD3CNR1 | |
| SCHEMBL2824516 | 0.93 | ACKR3 (0.36) | ACKR3TOP2AABCC2SMYD3CNR1 | |
| SCHEMBL2846474 | 0.93 | HTR4 (0.34) | TOP2AABCC2KCNH2HTR4 | |
| SCHEMBL2846475 | 0.93 | HTR4 (0.34) | TOP2AABCC2KCNH2HTR4 | |
| SCHEMBL2842898 | 0.91 | ABCC2 (0.39) | ABCC2HTR4 | |
| SCHEMBL2826840 | 0.91 | ABCC2 (0.39) | ABCC2HTR4 | |
| SCHEMBL2851247 | 0.91 | TOP2A (0.33) | ACKR3TOP2AABCC2KCNH2HTR4 | |
| SCHEMBL2849527 | 0.91 | PTGES (0.36) | TOP2AABCC2HTR4 | |
| SCHEMBL2851244 | 0.91 | TOP2A (0.33) | ACKR3TOP2AABCC2KCNH2HTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137574-B | Hydroxyalkyl thiadiazole derivatives | 第一三共株式会社 | 2021-12-28 | — | — | CN | disclosed |
| EP-3356361-B1 | HYDROXYALKYL THIADIAZOLE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2020-07-08 | — | — | EP | disclosed |
| US-10399968-B2 | Hydroxyalkyl thiadiazole derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-09-03 | — | — | US | disclosed |
| US-20180327399-A1 | HYDROXYALKYL THIADIAZOLE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2018-11-15 | — | — | US | disclosed |
| EP-3356361-A1 | HYDROXYALKYL THIADIAZOLE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2018-08-08 | — | — | EP | disclosed |
| EP-2226322-B1 | IMIDAZOLE CARBONYL COMPOUND | DAIICHI SANKYO CO LTD (JP) | 2015-01-21 | — | — | EP | disclosed |
| US-8927588-B2 | Imidazole carbonyl compound | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-01-06 | — | — | US | disclosed |
| US-20140073622-A1 | IMIDAZOLE CARBONYL COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-03-13 | — | — | US | disclosed |
| US-8536197-B2 | Imidazole carbonyl compound | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-09-17 | — | — | US | disclosed |
| US-20100311966-A1 | IMIDAZOLE CARBONYL COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-12-09 | — | — | US | disclosed |
| EP-2226322-A1 | IMIDAZOLE CARBONYL COMPOUND | Daiichi Sankyo Company, Limited (JP) | 2010-09-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10399968-B2 | Hydroxyalkyl thiadiazole derivatives | TOP1, TOP2B, TOP2A | ACKR3 3127/4885TOP2A 3/4885ABCC2 2306/4885 |
| US-20100311966-A1 | IMIDAZOLE CARBONYL COMPOUND | TOP1, TOP2B, TOP2A | ACKR3 4774/4885TOP2A 3/4885ABCC2 1441/4885 |
| US-20180327399-A1 | HYDROXYALKYL THIADIAZOLE DERIVATIVES | TOP1, TOP2B, TOP2A | ACKR3 3127/4885TOP2A 3/4885ABCC2 2306/4885 |
| US-20140073622-A1 | IMIDAZOLE CARBONYL COMPOUND | TOP1, TOP2B, TOP2A | ACKR3 4703/4885TOP2A 3/4885ABCC2 849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.