Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.32 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.32 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.32 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.32 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.32 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.32 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.32 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.32 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.32 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.32 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.32 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27340554 | 0.75 | HPGD (0.40) | HPGD | |
| SCHEMBL28900668 | 0.71 | KDM4E (0.53) | POLBKDM4EALDH1A1 | |
| SCHEMBL21822870 | 0.70 | PRKDC (0.61) | LMNAPRKDCKDM4EALDH1A1HPGD | |
| SCHEMBL21305428 | 0.66 | PTGDR2 (0.49) | LMNAPOLBALDH1A1PTGDR2HPGD | |
| SCHEMBL2424456 | 0.65 | MEN1 (0.45) | KDM4EALDH1A1HPGD | |
| SCHEMBL27159746 | 0.65 | PTGDR2 (0.51) | POLBALDH1A1PTGDR2HPGD | |
| SCHEMBL29964495 | 0.65 | PTGDR2 (0.51) | POLBALDH1A1PTGDR2HPGD | |
| SCHEMBL30933784 | 0.64 | PARP15 (0.38) | KDM4EALDH1A1 | |
| SCHEMBL17061451 | 0.64 | PTGDR2 (0.57) | POLBALDH1A1PTGDR2HPGD | |
| SCHEMBL31710828 | 0.64 | PKM (0.49) | LMNAKDM4EALDH1A1NTRK1NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111808086-B | Heterocyclic substituted styryl-4-phenylpyridine derivative, preparation method and medical application thereof | 上海海雁医药科技有限公司 | 2021-12-14 | — | — | CN | disclosed |
| CN-111808086-A | Heterocyclic substituted styryl-4-phenylpyridine derivative, preparation method and medical application thereof | 上海海雁医药科技有限公司 | 2020-10-23 | — | — | CN | disclosed |