SCHEMBL28476262

SCHEMBL28476262

Cc1ccc(-c2ccccc2I)c(C=O)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
C1R P00736 1/20 0.43
ELANE P08246 1/20 0.43
HCRTR1 O43613 1/20 0.42
HCRTR2 O43614 1/20 0.42
SRC P12931 1/20 0.39
ALDH1A1 P00352 4/20 0.38
TSHR P16473 1/20 0.38
MCL1 Q07820 1/20 0.38
ERN1 O75460 1/20 0.37
NPSR1 Q6W5P4 2/20 0.36
LMNA P02545 3/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
THRB P10828 1/20 0.35
BLM P54132 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
SMN1; SMN2 Q16637 2/20 0.34
MAPT P10636 2/20 0.34
RAB9A P51151 1/20 0.34
CYP2C9 P11712 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28468611 0.86 C1R (0.47) C1RELANEHCRTR1HCRTR2SRC
SCHEMBL24500913 0.79 LMNA (0.52) HCRTR1HCRTR2SRCALDH1A1TSHR
SCHEMBL28476090 0.79 ERN1 (0.50) C1RHCRTR1HCRTR2ALDH1A1MCL1
SCHEMBL18253147 0.77 MAOA (0.50) ELANESRCALDH1A1ERN1LMNA
SCHEMBL4851358 0.77 PSMB5 (0.46) ELANESRCALDH1A1TSHRERN1
SCHEMBL24625661 0.76 ELANE (0.45) C1RELANEALDH1A1TSHRNPSR1
SCHEMBL27016125 0.76 HSD11B1 (0.41) ELANESRCALDH1A1TSHRLMNA
SCHEMBL13106397 0.75 SRC (0.47) SRCALDH1A1TSHRMCL1ERN1
SCHEMBL31551687 0.75 ALDH1A1 (0.50) ELANESRCALDH1A1TSHRNPSR1
SCHEMBL4851355 0.74 ELANE (0.48) ELANESRCALDH1A1TSHRERN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111689973-A Dibenzocaprolactam pyrazolidine compound, preparation method and application 朱翠萍 2020-09-22 CN claimed
CN-111689973-A Dibenzocaprolactam pyrazolidine compound, preparation method and application 朱翠萍 2020-09-22 CN disclosed