Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL6 | P41182 | 2/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.39 |
| ▸ | CDK19 | Q9BWU1 | 3/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 6/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CDK9 | P50750 | 2/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30388156 | 0.78 | ALK (0.42) | BCL6ALKCDK19LRRK2JAK2 | |
| SCHEMBL29129582 | 0.78 | MAPT (0.52) | JAK2ALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL6214605 | 0.74 | MEN1 (0.53) | ALDH1A1HTTSMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL12138409 | 0.73 | ALDH1A1 (0.44) | ALDH1A1HTTSMN1; SMN2CA1CA2 | |
| SCHEMBL28076893 | 0.73 | MEN1 (0.35) | ALDH1A1HTTSMN1; SMN2L3MBTL1CA1 | |
| SCHEMBL30615428 | 0.72 | MAPK1 (0.58) | ALKCDK19LRRK2ALDH1A1HTT | |
| SCHEMBL17815796 | 0.71 | PRMT1 (0.53) | ALDH1A1HTTSMN1; SMN2AURKBCA1 | |
| SCHEMBL2708359 | 0.70 | ALDH1A1 (0.38) | ALDH1A1HTTSMN1; SMN2L3MBTL1CA1 | |
| SCHEMBL7885090 | 0.70 | LMNA (0.41) | ALDH1A1SMN1; SMN2CA1CA2CA7 | |
| SCHEMBL18803141 | 0.70 | ALDH1A1 (0.36) | ALDH1A1HTTSMN1; SMN2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111848605-B | Substituted pyrido [3,4-b ] pyrazin-2 (1H) -one compound, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2023-05-02 | — | — | CN | disclosed |
| CN-111848605-A | Substituted pyrido [3,4-b ] pyrazine-2 (1H) -ketone compound, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2020-10-30 | — | — | CN | disclosed |