Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | MAOA | P21397 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28474298 | 0.95 | LMNA (0.61) | LMNAMAOAMAOBCYP19A1SIGMAR1 | |
| SCHEMBL3878665 | 0.90 | LMNA (0.53) | LMNAMAOAMAOBCYP19A1NPC1 | |
| SCHEMBL3692999 | 0.83 | LMNA (0.66) | LMNANPC1RAB9AAKR1B10AKR1B1 | |
| SCHEMBL8044825 | 0.82 | THRB (0.47) | LMNAMAOAMAOBCYP19A1SIGMAR1 | |
| SCHEMBL28472237 | 0.81 | LMNA (0.47) | LMNAMAOAMAOBCYP19A1NPC1 | |
| SCHEMBL6696643 | 0.81 | MAOA (0.46) | LMNAMAOAMAOBCYP19A1SIGMAR1 | |
| Phenprobamate SCHEMBL134496 | 0.81 | LMNA (1.00) | LMNANPC1RAB9ASMN1; SMN2RECQL | |
| SCHEMBL6689368 | 0.80 | MAOA (0.45) | LMNAMAOAMAOBCYP19A1CYP4F2 | |
| SCHEMBL6696590 | 0.80 | MAOA (0.45) | LMNAMAOAMAOBCYP19A1CYP4F2 | |
| SCHEMBL5182130 | 0.80 | LMNA (0.43) | LMNAMAOAMAOBCYP19A1FKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107295798-B | Benzazepine dicarboxamide compound | 豪夫迈·罗氏有限公司 | 2020-10-30 | — | — | CN | disclosed |