Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 7/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.35 |
| ▸ | HTR3B | O95264 | 2/20 | 0.35 |
| ▸ | HTR3A | P46098 | 2/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | BPTF | Q12830 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | NCF1 | P14598 | 1/20 | 0.33 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5866411 | 0.82 | — | — | |
| SCHEMBL30724578 | 0.81 | LMNA (0.35) | ALDH1A1KDM4ELMNA | |
| SCHEMBL1420015 | 0.67 | ADRB1 (0.36) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL17067817 | 0.67 | KDM4E (0.42) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL28033389 | 0.65 | ADRB1 (0.35) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4703910 | 0.65 | ADRB1 (0.35) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL28705412 | 0.63 | ADRB1 (0.35) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL27668244 | 0.63 | ADRB1 (0.33) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL5062726 | 0.63 | MGLL (0.33) | — | |
| SCHEMBL6631277 | 0.62 | CHRNB2 (0.37) | HTR3AHRH1CASP1CASP4CASP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113329999-A | Novel substituted quinoline-8-carbonitrile derivatives having androgen receptor degrading activity and uses thereof | 冰洲石生物科技公司 | 2021-08-31 | — | — | CN | claimed |
| CN-112154146-A | Serine threonine kinase (AKT) degradation/disruption compounds and methods of use | 西奈山伊坎医学院 | 2020-12-29 | — | — | CN | claimed |
| CN-110741004-B | Compounds and methods for rapid accelerated targeted degradation of fibrosarcoma polypeptides | 阿尔维纳斯运营股份有限公司 | 2023-10-17 | — | — | CN | disclosed |
| CN-107108698-B | Macrocyclic peptides as immunomodulators | 百时美施贵宝公司 | 2022-04-29 | — | — | CN | disclosed |
| CN-111925341-A | Preparation method of piperazine | 山东达民化工股份有限公司 | 2020-11-13 | — | — | CN | disclosed |
| CN-111868146-A | Composite materials comprising mechanical ligands | 纳诺科尔有限公司 | 2020-10-30 | — | — | CN | disclosed |
| CN-110997679-A | Bicyclic compounds and methods of use | 拜欧赛里克斯公司 | 2020-04-10 | — | — | CN | disclosed |