Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 5/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | SPR | P35270 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2859967 | 0.88 | KEAP1 (0.52) | MAPTPOLBSMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL2854321 | 0.88 | MAPT (0.53) | MAPTPOLBSMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL2853814 | 0.83 | LIPE (0.43) | MAPTPOLBSMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL2854177 | 0.79 | CCR1 (0.58) | MAPTPOLBSMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL2858203 | 0.79 | MAPT (0.68) | MAPTPOLBSMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL2859264 | 0.78 | MAPT (0.46) | MAPTPOLBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL2854614 | 0.78 | MAPT (0.49) | MAPTPOLBSMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL2857175 | 0.78 | MAPT (0.57) | MAPTPOLBSMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL2862087 | 0.78 | MAPT (0.51) | MAPTPOLBSMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL10364986 | 0.77 | MAPT (0.65) | MAPTPOLBSMN1; SMN2KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |