Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenylmethane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.63 |
| ▸ | HTR2A | P28223 | 3/20 | 0.52 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 2/20 | 0.52 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.48 |
| ▸ | IDH1 | O75874 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylmethane SCHEMBL4640193 | 1.00 | CALM1 (0.63) | CALM1HTR2ALOXL2CYP2A6SMN1; SMN2 | |
| Diphenylmethane SCHEMBL4556684 | 0.86 | CALM1 (0.75) | CALM1TDP1LTA4HPLA2G10PLA2G2A | |
| Benzyl Alcohol SCHEMBL9100558 | 0.84 | TSHR (0.74) | CALM1HTR2ALOXL2CYP2A6SMN1; SMN2 | |
| Diphenylmethane SCHEMBL11211579 | 0.83 | CALM1 (0.80) | CALM1HTR2ALOXL2CYP2A6SMN1; SMN2 | |
| Diphenylmethane SCHEMBL10394702 | 0.83 | CALM1 (0.92) | CALM1LOXL2TDP1LTA4HPLA2G10 | |
| Phenylethyl Alcohol SCHEMBL8757087 | 0.82 | TDP1 (0.80) | HTR2ALOXL2CYP2A6SMN1; SMN2TAAR1 | |
| Benzylamine SCHEMBL11763370 | 0.82 | LOXL2 (0.70) | HTR2ALOXL2CYP2A6SMN1; SMN2TAAR1 | |
| Diphenylmethane SCHEMBL16760974 | 0.81 | CALM1 (0.46) | CALM1HTR2ALOXL2CYP2A6SMN1; SMN2 | |
| Ethylbenzene SCHEMBL4654072 | 0.80 | TP53 (0.67) | HTR2ALOXL2CYP2A6SMN1; SMN2TAAR1 | |
| (Chloromethyl)Benzene SCHEMBL28303369 | 0.80 | HTR2A (0.48) | CALM1HTR2ALOXL2CYP2A6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111825831-A | Epoxy resin compound with high phosphorus and oxazolidinone content, preparation method and curing composition containing compound | 长春人造树脂厂股份有限公司 | 2020-10-27 | — | — | CN | disclosed |