Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 6/20 | 0.39 |
| ▸ | CHRM3 known ✓ | P20309 | 6/20 | 0.39 |
| ▸ | CHRM2 known ✓ | P08172 | 5/20 | 0.38 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.38 |
| ▸ | SCN1A | P35498 | 2/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.37 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29050268 | 0.82 | SMN1; SMN2 (0.46) | CHRM5CHRM1CHRM3MAPTBLM | |
| Hydrochloric Acid SCHEMBL28126462 | 0.80 | CHRM5 (0.40) | CHRM5CHRM1CHRM3MAPTBLM | |
| Hydrochloric Acid SCHEMBL29179325 | 0.77 | CYP3A4 (0.42) | CHRM5CHRM1CHRM3MAPTBLM | |
| SCHEMBL28761585 | 0.77 | SCN1A (0.42) | CHRM5CHRM1CHRM3MAPTBLM | |
| SCHEMBL8588191 | 0.76 | CHRM1 (0.40) | CHRM5CHRM1CHRM3MAPTBLM | |
| Hydrochloric Acid SCHEMBL22409396 | 0.74 | SCN1A (0.43) | CHRM5CHRM1CHRM3MAPTBLM | |
| Hydrochloric Acid SCHEMBL28223992 | 0.74 | CYP3A4 (0.39) | CHRM5CHRM1CHRM3MAPTBLM | |
| SCHEMBL24292362 | 0.73 | SCN1A (0.39) | CHRM5CHRM1CHRM3MAPTBLM | |
| SCHEMBL28965480 | 0.73 | SCN1A (0.39) | CHRM5CHRM1CHRM3MAPTBLM | |
| SCHEMBL14838721 | 0.73 | HSD17B10 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113663361-A | Method for extracting polyphenol compounds in olive leaves by using eutectic solvent | 河南工业大学 | 2021-11-19 | — | — | CN | claimed |
| CN-113476495-A | Method for extracting polyphenol compounds in rosemary by using eutectic solvent | 河南工业大学 | 2021-10-08 | — | — | CN | claimed |
| CN-113663361-A | Method for extracting polyphenol compounds in olive leaves by using eutectic solvent | 河南工业大学 | 2021-11-19 | — | — | CN | disclosed |
| CN-113476495-A | Method for extracting polyphenol compounds in rosemary by using eutectic solvent | 河南工业大学 | 2021-10-08 | — | — | CN | disclosed |
| CN-107954859-B | Method for separating acrylic acid/triisobutene azeotrope | 万华化学集团股份有限公司 | 2020-11-24 | — | — | CN | disclosed |