Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 5/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.40 |
| ▸ | ULK1 | O75385 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.35 |
| ▸ | CCNK | O75909 | 3/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.35 |
| ▸ | CDK7 | P50613 | 2/20 | 0.35 |
| ▸ | CCNH | P51946 | 2/20 | 0.35 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.35 |
| ▸ | CDK9 | P50750 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30397931 | 1.00 | CDK2 (0.41) | CDK2KDRHSD11B1MAPK3ULK1 | |
| SCHEMBL30397298 | 0.90 | CDK2 (0.40) | CDK2KDRHSD11B1MAPK3ULK1 | |
| SCHEMBL25224397 | 0.90 | CDK2 (0.40) | CDK2KDRHSD11B1MAPK3ULK1 | |
| SCHEMBL22998319 | 0.83 | ULK1 (0.44) | CDK2KDRHSD11B1MAPK3ULK1 | |
| SCHEMBL25209416 | 0.82 | GRM5 (0.38) | CDK2KDRMAPK3ULK1PTK2 | |
| SCHEMBL30397703 | 0.82 | GRM5 (0.38) | CDK2KDRMAPK3ULK1PTK2 | |
| SCHEMBL30397992 | 0.80 | MAPK3 (0.46) | CDK2KDRHSD11B1MAPK3ULK1 | |
| SCHEMBL30397130 | 0.80 | MAPK3 (0.46) | CDK2KDRHSD11B1MAPK3ULK1 | |
| SCHEMBL25522696 | 0.80 | ULK1 (0.55) | CDK2KDRMAPK3ULK1CDK1 | |
| SCHEMBL28486909 | 0.79 | ULK1 (0.42) | CDK2KDRMAPK3ULK1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |