Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GABRP | O00591 | 2/20 | 0.45 |
| ▸ | GABRD | O14764 | 2/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.45 |
| ▸ | GABRE | P78334 | 2/20 | 0.45 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL27964415 | 0.87 | LMNA (0.54) | KDM4EADRA2AADRA2CLMNAHIF1A | |
| Acrylic Acid SCHEMBL28953156 | 0.86 | LMNA (0.45) | HCAR2KDM4EADRA2AADRA2CLMNA | |
| Acetone SCHEMBL27900518 | 0.85 | LMNA (0.52) | KDM4EADRA2AADRA2CLMNAHIF1A | |
| Acetic Acid SCHEMBL28010039 | 0.85 | LMNA (0.52) | KDM4EADRA2AADRA2CLMNAHIF1A | |
| Acetic Acid SCHEMBL432495 | 0.85 | LMNA (0.52) | KDM4EADRA2AADRA2CLMNAHIF1A | |
| Oxalic Acid SCHEMBL28194607 | 0.85 | LMNA (0.52) | KDM4EADRA2AADRA2CLMNAHIF1A | |
| Acetic Acid SCHEMBL28490384 | 0.85 | LMNA (0.52) | KDM4EADRA2AADRA2CLMNAHIF1A | |
| Formic Acid SCHEMBL28071381 | 0.83 | ADRA2A (0.50) | KDM4EADRA2AADRA2CLMNAHIF1A | |
| (1S,2R)-Phenylpropanolamine SCHEMBL16755253 | 0.82 | KDM4E (0.74) | HCAR2KDM4EADRA2AADRA2CLMNA | |
| Methyl Alcohol SCHEMBL5316422 | 0.82 | ADRA2A (0.58) | KDM4EADRA2AADRA2CLMNAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112004520-A | Modified release drug powder compositions comprising a gastric retentive raft forming system with triggered pulsed drug release | 特瑞斯制药公司 | 2020-11-27 | — | — | CN | disclosed |