SCHEMBL28488309

SCHEMBL28488309

NCCCCn1nnc2cc(Br)ccc2c1=O

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.45
MEN1 O00255 4/20 0.45
HTT P42858 1/20 0.45
ALDH1A1 P00352 1/20 0.43
HDAC3 O15379 1/20 0.42
HDAC4 P56524 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC2 Q92769 1/20 0.42
HDAC10 Q969S8 1/20 0.42
HDAC11 Q96DB2 1/20 0.42
HDAC8 Q9BY41 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
HDAC9 Q9UKV0 1/20 0.42
HDAC5 Q9UQL6 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17950532 0.80 NPC1 (0.44) KMT2AMEN1ALDH1A1HDAC3HDAC4
SCHEMBL17950737 0.76 MAPK1 (0.54) KMT2AMEN1HDAC3HDAC4HDAC1
SCHEMBL17950740 0.76 MEN1 (0.68) KMT2AMEN1HTTALDH1A1HDAC3
SCHEMBL17950752 0.73 NPC1 (0.43) KMT2AMEN1HTTALDH1A1
SCHEMBL10990947 0.73 MEN1 (0.45) KMT2AMEN1HTTALDH1A1
SCHEMBL17950528 0.73 NPC1 (0.43) KMT2AMEN1ALDH1A1HDAC3HDAC4
SCHEMBL10585374 0.71 NPC1 (0.47) KMT2AMEN1
SCHEMBL17950436 0.71 GPR139 (0.47) KMT2AMEN1HTTALDH1A1
SCHEMBL17950590 0.71 SMN1; SMN2 (0.44) KMT2AMEN1HTTALDH1A1
SCHEMBL12963695 0.70 ALDH1A1 (0.64) KMT2AMEN1HTTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104530037-B Triazine heterocyclic compound with nematicidal activity and preparation method and application thereof 华东理工大学 2020-12-18 CN disclosed