SCHEMBL28488673

SCHEMBL28488673

O=c1c2ccc(C(F)(F)F)cc2nnn1CCCBr

nearest known ligand 0.42

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
GPR139 Q6DWJ6 8/20 0.42
ALDH1A1 P00352 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
PKM P14618 1/20 0.40
PARP1 P09874 1/20 0.38
KCNH2 Q12809 1/20 0.37
HRH3 Q9Y5N1 1/20 0.37
CTSD P07339 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28487231 0.87 GPR139 (0.43) GPR139ALDH1A1MEN1KMT2APKM
SCHEMBL17950590 0.83 SMN1; SMN2 (0.44) GPR139ALDH1A1MEN1KMT2A
SCHEMBL17950436 0.80 GPR139 (0.47) GPR139ALDH1A1MEN1KMT2A
SCHEMBL17950528 0.79 NPC1 (0.43) GPR139ALDH1A1MEN1KMT2A
SCHEMBL17950445 0.78 GPR139 (0.48) GPR139ALDH1A1MEN1KMT2A
SCHEMBL17950668 0.77 GPR139 (0.52) GPR139ALDH1A1MEN1KMT2APKM
SCHEMBL17950675 0.76 PKM (0.46) GPR139MEN1KMT2APKMPARP1
SCHEMBL5816179 0.76 KMT2A (0.68) ALDH1A1MEN1KMT2A
SCHEMBL30778076 0.76 GPR139 (0.51) GPR139ALDH1A1MEN1KMT2APKM
SCHEMBL17950503 0.73 KMT2A (0.40) ALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104530037-B Triazine heterocyclic compound with nematicidal activity and preparation method and application thereof 华东理工大学 2020-12-18 CN disclosed