SCHEMBL28488982

SCHEMBL28488982

COC(=O)C(F)(F)F.O=C(O)CC1CNC1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A1 P30531 2/20 0.44
GABRA5 P31644 2/20 0.44
GABRB2 P47870 2/20 0.44
SLC6A12 P48065 2/20 0.44
SLC6A11 P48066 2/20 0.44
SLC6A13 Q9NSD5 2/20 0.44
GABRA1 P14867 1/20 0.44
GABRR1 P24046 1/20 0.44
GABRA4 P48169 1/20 0.44
CHRNB2 P17787 5/20 0.33
CHRNA4 P43681 5/20 0.33
CHRNA3 P32297 3/20 0.33
CHRNB4 P30926 2/20 0.33
CHRNA7 P36544 1/20 0.33
FFAR4 Q5NUL3 3/20 0.32
SLC6A2 P23975 3/20 0.31
SLC6A4 P31645 3/20 0.31
SLC6A3 Q01959 3/20 0.31
CYP1A2 P05177 1/20 0.30
CYP3A4 P08684 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL1663586 0.82 SLC6A12 (0.53) SLC6A1GABRA5GABRB2SLC6A12SLC6A11
Trifluoroacetic Acid SCHEMBL18493226 0.78 BRD4 (0.38) SLC6A1GABRA5GABRB2SLC6A12SLC6A11
SCHEMBL2569289 0.78
Hydrochloric Acid SCHEMBL177340 0.75
SCHEMBL1663589 0.74 SLC6A1 (0.32) SLC6A1GABRA5GABRB2SLC6A12SLC6A11
Trifluoroacetic Acid SCHEMBL2573227 0.74 CHRNB2 (0.38) SLC6A1GABRA5GABRB2SLC6A12SLC6A11
SCHEMBL111507 0.71
SCHEMBL956931 0.70
SCHEMBL2918774 0.69 SLC6A11 (0.75) SLC6A1GABRA5GABRB2SLC6A12SLC6A11
SCHEMBL30299155 0.69 SLC6A11 (0.75) SLC6A1GABRA5GABRB2SLC6A12SLC6A11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106471067-B Azetidine substituted fluorescent compounds 霍华德休斯医学研究所 2020-12-08 CN disclosed