Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.51 |
| ▸ | IGF1R | P08069 | 2/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.51 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GABRP | O00591 | 4/20 | 0.43 |
| ▸ | GABRD | O14764 | 4/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23119573 | 0.88 | CDK5 (0.59) | CDK5CDK5R1AURKAMAPTGABRP | |
| SCHEMBL30565799 | 0.84 | NTRK1 (0.56) | NTRK1IGF1RFGFR1NTRK2NTRK3 | |
| SCHEMBL18741408 | 0.84 | NTRK1 (0.56) | NTRK1IGF1RFGFR1NTRK2NTRK3 | |
| SCHEMBL6002037 | 0.80 | ALDH1A1 (0.68) | NTRK1IGF1RFGFR1NTRK2MAPT | |
| SCHEMBL29367625 | 0.77 | LMNA (0.65) | AURKAMAPTALDH1A1HPGDGABRP | |
| SCHEMBL699273 | 0.77 | LMNA (0.65) | AURKAMAPTALDH1A1HPGDGABRP | |
| SCHEMBL30615496 | 0.76 | CDK5 (0.48) | CDK5CDK5R1AURKAGABRPGABRD | |
| SCHEMBL6982369 | 0.75 | KDM4E (0.60) | CDK5CDK5R1MAPTALDH1A1HPGD | |
| SCHEMBL9994946 | 0.74 | HTT (0.56) | AURKAMAPTGABRPGABRDGABRA1 | |
| SCHEMBL4098385 | 0.74 | AURKA (0.56) | AURKAMAPTALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111868037-B | Fused cyclic urea derivatives as CRHR2 antagonists | 拉夸里亚创药株式会社 | 2023-10-13 | — | — | CN | disclosed |
| CN-111868037-A | Fused cyclic urea derivatives as CRHR2 antagonists | 拉夸里亚创药株式会社 | 2020-10-30 | — | — | CN | disclosed |