SCHEMBL28501586

SCHEMBL28501586

COc1ccc(/C(C#Cc2ccccc2)=N\O)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 5/20 0.51
NPC1 O15118 4/20 0.51
MEN1 O00255 1/20 0.51
POLB P06746 1/20 0.51
KMT2A Q03164 1/20 0.51
NLRP3 Q96P20 1/20 0.51
SMN1; SMN2 Q16637 2/20 0.47
ALDH1A1 P00352 2/20 0.47
APP P05067 2/20 0.46
CES2 O00748 1/20 0.45
CES1 P23141 1/20 0.45
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
KDM4E B2RXH2 1/20 0.41
VCP P55072 1/20 0.41
MAPT P10636 3/20 0.40
CYP1A2 P05177 2/20 0.40
CYP3A4 P08684 2/20 0.40
CYP2C9 P11712 2/20 0.40
CYP2C19 P33261 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28513684 0.94 RAB9A (0.48) RAB9ANPC1MEN1POLBKMT2A
SCHEMBL30572187 0.86 NPC1 (0.50) RAB9ANPC1MEN1POLBKMT2A
SCHEMBL28501871 0.83 APP (0.44) RAB9ANPC1MEN1KMT2ASMN1; SMN2
SCHEMBL28499562 0.82 VCP (0.60) RAB9ANPC1MEN1POLBKMT2A
SCHEMBL28513256 0.79 VCP (0.40) RAB9ANPC1MEN1KMT2ASMN1; SMN2
SCHEMBL28509926 0.79 VCP (0.40) RAB9ANPC1MEN1KMT2ASMN1; SMN2
SCHEMBL28503148 0.79 MEN1 (0.47) MEN1KMT2ASMN1; SMN2ALDH1A1APP
SCHEMBL10069798 0.78 APP (0.72) RAB9ANPC1MEN1POLBKMT2A
SCHEMBL28509442 0.76 ASIC3 (0.45) RAB9ANPC1MEN1KMT2ASMN1; SMN2
SCHEMBL28501872 0.76 VCP (0.51) RAB9ANPC1MEN1POLBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112062735-B Synthesis method of isoselenazole derivative 温州大学 2022-11-08 CN disclosed
CN-112159364-B Synthetic method of isothiazole derivative 温州大学 2022-06-24 CN disclosed
CN-112159364-A Synthetic method of isothiazole derivative 温州大学 2021-01-01 CN disclosed
CN-112062735-A Synthesis method of isoselenazole derivative 温州大学 2020-12-11 CN disclosed