Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | OGG1 | O15527 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.52 |
| ▸ | NAMPT | P43490 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MLYCD | O95822 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21590151 | 1.00 | ALDH1A1 (0.56) | ALDH1A1OGG1KMT2AOPRM1OPRD1 | |
| SCHEMBL21590324 | 1.00 | ALDH1A1 (0.56) | ALDH1A1OGG1KMT2AOPRM1OPRD1 | |
| SCHEMBL889069 | 0.87 | MLYCD (0.63) | ALDH1A1OGG1KMT2AOPRM1OPRD1 | |
| SCHEMBL24386356 | 0.84 | LMNA (0.56) | ALDH1A1KMT2ANAMPTHPGDNPC1 | |
| SCHEMBL9668334 | 0.84 | MPO (0.52) | ALDH1A1KMT2ANAMPTHPGDNPC1 | |
| SCHEMBL5800429 | 0.84 | LMNA (0.56) | ALDH1A1KMT2ANAMPTHPGDNPC1 | |
| SCHEMBL3038615 | 0.83 | ALDH1A1 (0.61) | ALDH1A1OGG1KMT2AHPGDNPC1 | |
| SCHEMBL15087817 | 0.82 | MEN1 (0.58) | ALDH1A1KMT2ANAMPTHPGDNPC1 | |
| SCHEMBL19835585 | 0.82 | MEN1 (0.58) | ALDH1A1KMT2ANAMPTHPGDNPC1 | |
| SCHEMBL17011381 | 0.82 | KDM4E (0.56) | ALDH1A1KMT2ANAMPTHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118043324-A | Pyrrolo [2,3-b ] pyrazine-based bifunctional compounds as HPK1 degradants and uses thereof | 百济神州有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-112239473-B | Process for preparing tricyclic compounds as HPK1 inhibitors | 百济神州(北京)生物科技有限公司 | 2023-12-08 | — | — | CN | disclosed |
| CN-115073474-A | Pyrrolo [2,3-b ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2022-09-20 | — | — | CN | disclosed |
| CN-115028639-A | Pyrrolo [2,3-b ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-114127067-A | Tricyclic compounds as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2022-03-01 | — | — | CN | disclosed |
| CN-114096536-A | Pyrrolo [2,3-b ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2022-02-25 | — | — | CN | disclosed |
| CN-113166139-A | Pyrrolo [2,3-b ] pyridines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-07-23 | — | — | CN | disclosed |
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |
| CN-112239473-A | Tricyclic compounds as HPK1 inhibitors | 百济神州(北京)生物科技有限公司 | 2021-01-19 | — | — | CN | disclosed |