Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HEXD | Q8WVB3 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2856260 | 0.88 | TSHR (0.46) | SMN1; SMN2HPGDLMNATRPV1TSHR | |
| SCHEMBL2857628 | 0.84 | NPC1 (0.40) | SMN1; SMN2ALDH1A1HPGDLMNATP53 | |
| SCHEMBL2857977 | 0.84 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1HTTHPGDLMNA | |
| SCHEMBL2848518 | 0.84 | ALDH1A1 (0.58) | SMN1; SMN2ALDH1A1HTTHPGDLMNA | |
| SCHEMBL2855603 | 0.83 | P2RX1 (0.44) | HPGDLMNANPSR1POLB | |
| SCHEMBL2861682 | 0.83 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1HTTHPGDLMNA | |
| SCHEMBL2856388 | 0.83 | TRPV1 (0.51) | SMN1; SMN2ALDH1A1HTTLMNAL3MBTL1 | |
| SCHEMBL2850129 | 0.83 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1HTTHPGDCYP1A2 | |
| SCHEMBL2854686 | 0.83 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1HTTHPGDL3MBTL1 | |
| SCHEMBL2852539 | 0.83 | LMNA (0.52) | HPGDLMNACYP1A2CYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |