Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
| ▸ | TEK | Q02763 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.30 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29112575 | 0.81 | DGAT1 (0.41) | DGAT1EGFRIGF1RSRCFLT4 | |
| SCHEMBL28562824 | 0.78 | DGAT1 (0.40) | DGAT1EGFRIGF1RSRCFLT4 | |
| SCHEMBL28645169 | 0.78 | DGAT1 (0.39) | DGAT1PDE10A | |
| SCHEMBL23997682 | 0.77 | KLKB1 (0.47) | DGAT1EGFRIGF1RSRCFLT4 | |
| SCHEMBL21712951 | 0.75 | KLKB1 (0.37) | DGAT1EGFRIGF1RSRCFLT4 | |
| SCHEMBL4394992 | 0.74 | DGAT1 (0.43) | DGAT1PDE10AKLKB1 | |
| SCHEMBL17796240 | 0.74 | ALDH1A1 (0.34) | DGAT1EGFRIGF1RSRCFLT4 | |
| SCHEMBL29023457 | 0.73 | DGAT1 (0.44) | DGAT1EGFRIGF1RSRCFLT4 | |
| SCHEMBL27858492 | 0.73 | DGAT1 (0.36) | DGAT1EGFRIGF1RSRCFLT4 | |
| SCHEMBL4394623 | 0.73 | DGAT1 (0.39) | DGAT1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |