Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 6/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
| ▸ | TEK | Q02763 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21712951 | 0.86 | KLKB1 (0.37) | KLKB1NPC1DGAT1EGFRIGF1R | |
| SCHEMBL17222119 | 0.83 | KLKB1 (0.47) | KLKB1NPC1DGAT1EGFRIGF1R | |
| SCHEMBL25254975 | 0.83 | KLKB1 (0.47) | KLKB1NPC1DGAT1MAPT | |
| SCHEMBL5654607 | 0.80 | KLKB1 (0.45) | KLKB1NPC1DGAT1 | |
| SCHEMBL28503532 | 0.77 | DGAT1 (0.41) | KLKB1NPC1DGAT1EGFRIGF1R | |
| SCHEMBL17222067 | 0.74 | KLKB1 (0.45) | KLKB1NPC1DGAT1EGFRIGF1R | |
| SCHEMBL12984274 | 0.74 | KLKB1 (0.41) | KLKB1NPC1DGAT1EGFRIGF1R | |
| SCHEMBL29977642 | 0.74 | KLKB1 (0.39) | KLKB1NPC1DGAT1MAPT | |
| SCHEMBL17796240 | 0.72 | ALDH1A1 (0.34) | NPC1DGAT1EGFRIGF1RSRC | |
| SCHEMBL874860 | 0.72 | GPR35 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2922535-B1 | THROMBIN INHIBITORS | MERCK SHARP & DOHME (US) | 2021-11-10 | — | — | EP | disclosed |