Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MELK | Q14680 | 6/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.47 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.47 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.47 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.47 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.47 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8256016 | 0.87 | LMNA (0.52) | LMNADRD4RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL436539 | 0.85 | DRD4 (0.50) | LMNAMAPTDRD4RAB9ANPC1 | |
| SCHEMBL12359040 | 0.85 | DRD4 (0.67) | LMNADRD4RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL30860308 | 0.84 | MELK (0.54) | LMNADRD4RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL22567606 | 0.84 | DRD4 (0.55) | LMNADRD4RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL20710180 | 0.83 | DRD4 (0.51) | LMNAMAPTDRD4RAB9ANPC1 | |
| SCHEMBL13227073 | 0.83 | HPGD (0.51) | LMNAMAPTDRD4RAB9ANPC1 | |
| SCHEMBL13808932 | 0.82 | DRD4 (0.47) | LMNADRD4RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1361808 | 0.81 | ALDH1A1 (0.50) | LMNADRD4RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4490990 | 0.81 | DRD4 (0.46) | LMNADRD4RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |