Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MELK | Q14680 | 8/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.47 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.47 |
| ▸ | NUAK1 | O60285 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.47 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.47 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.47 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4490990 | 0.95 | DRD4 (0.46) | DRD4LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28073437 | 0.90 | DRD4 (0.42) | DRD4LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17976084 | 0.89 | DRD4 (0.48) | DRD4LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4487965 | 0.88 | DRD4 (0.50) | DRD4LMNASMN1; SMN2MELKCHEK1 | |
| SCHEMBL3158672 | 0.88 | DRD4 (0.49) | DRD4LMNAHRH3ALDH1A1GFER | |
| SCHEMBL30921473 | 0.88 | DRD4 (0.49) | DRD4LMNAMAPK1HRH3ALDH1A1 | |
| SCHEMBL24538671 | 0.87 | DRD4 (0.49) | DRD4LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4481019 | 0.87 | LMNA (0.46) | DRD4LMNAALDH1A1KDM4ETSHR | |
| SCHEMBL8256016 | 0.87 | LMNA (0.52) | DRD4LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7347657 | 0.87 | LMNA (0.49) | LMNANPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 212 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3747864-B1 | A METHOD FOR PREPARING METHYL (Z)-3-[[4-[METHYL[2-(4-METHYL-1-PIPERAZINYL)ACETYL]AMINO]PHENYL]AMINO]PHENYLMETHYLENE)-OXINDOLE-6-CARBOXYLATE (INTEDANIB, NINTEDANIB) | Midas Pharma GmbH (DE) | 2025-01-08 | — | — | EP | claimed |
| CN-115181078-B | Synthesis method of Nidamib key intermediate | 安徽修一制药有限公司 | 2024-07-19 | — | — | CN | claimed |
| US-20240051920-A1 | AN IMPROVED HIGHLY EFFICIENT PROCESS FOR THE PREPARATION OF NINTEDANIB AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | BDR LIFESCIENCES PRIVATE LIMITED (IN) | 2024-02-15 | — | — | US | claimed |
| CN-111465594-B | Synthesis of 2-indolinones known as intermediates for the preparation of Nidamibu | 费米有限公司 | 2023-11-07 | — | — | CN | claimed |
| CN-111662223-B | Indolinone derivatives and process for preparing intermediates thereof | 四川科伦药物研究院有限公司 | 2023-07-14 | — | — | CN | claimed |
| EP-3710427-B1 | SYNTHESIS OF A 2-INDOLINONE DERIVATIVE KNOWN AS INTERMEDIATE FOR PREPARING NINTEDANIB | FERMION OY (FI) | 2023-03-08 | — | — | EP | claimed |
| CN-111848486-B | Method for preparing ethanesulfonic acid nintedanib | 赤峰经方医药技术开发有限责任公司 | 2022-12-27 | — | — | CN | claimed |
| CN-115181078-A | Synthesis method of nintedanib key intermediate | 安徽修一制药有限公司 | 2022-10-14 | — | — | CN | claimed |
| US-11261158-B2 | Synthesis of 2-indolinone derivatives | FERMION OY (FI) | 2022-03-01 | — | — | US | claimed |
| EP-3747864-A1 | A METHOD FOR PREPARING METHYL (Z)-3-[[4-[METHYL[2-(4-METHYL-1-PIPERAZINYL)ACETYL]AMINO]PHENYL]AMINO]PHENYLMETHYLENE)-OXINDOLE-6-CARBOXYLATE (INTEDANIB, NINTEDANIB) | ZENTIVA, K.S. (CZ) | 2020-12-09 | — | — | EP | claimed |
| US-20200299275-A1 | SYNTHESIS OF 2-INDOLINONE DERIVATIVES | FERMION OY (FI) | 2020-09-24 | — | — | US | claimed |
| EP-3328831-B1 | A METHOD FOR PREPARING METHYL (Z)-3-[[4-[METHYL[2-(4-METHYL-1-PIPERAZINYL)ACETYL]AMINO]PHENYL]AMINO]PHENYLMETHYLENE)-OXINDOLE-6-CARBOXYLATE (INTEDANIB, NINTEDANIB) | ZENTIVA KS (CZ) | 2020-07-29 | — | — | EP | claimed |
| US-20180215735-A1 | METHOD FOR PREPARING METHYL (Z)-3-[[4-[METHYL[2-(4-METHYL-1-PIPERAZINYL)ACETYL]AMINO]PHEHYL]AMINO]PHENYLMETHYLENE)-OXINDOLE-6-CARBOXYLATE (INTEDANIB, NINTEDANIB) | ZENTIVA K.S. (CZ) | 2018-08-02 | — | — | US | claimed |
| US-20170174625-A1 | PREPARATION METHOD OF NINTEDANIB | SUZHOU MIRACPHARMA TECHNOLOGY CO., LTD. (CN) | 2017-06-22 | — | — | US | claimed |
| CN-104844499-B | One kettle way prepares the synthetic method of Nintedanib | 北京康立生医药技术开发有限公司 | 2017-03-08 | — | — | CN | claimed |
| CN-104844499-A | Synthetic method for preparing Nintedanib through one-pot process | BEIJING KANG LISHENG PHARMACEUTICAL TECHNOLOGY DEV CO LTD | 2015-08-19 | — | — | CN | claimed |
| CN-104262232-A | Method for preparing nintedanib | SUZHOU MIRACPHARMA TECHNOLOGY CO LTD | 2015-01-07 | — | — | CN | claimed |
| WO-2025233641-A1 | NOVEL PHOTOINDUCIBLE KINASE INHIBITORS FOR TREATING PROLIFERATIVE AND VASOPROLIFERATIVE DISEASES | SEMMELWEIS EGYETEM (HU) | 2025-11-13 | — | — | WO | disclosed |
| CN-1319090-A | Novel substuted indolimones, their preparation process and use as medicine | BOEHRINGER INGELHEIM PHARMA (DE) | 2001-10-24 | — | — | CN | disclosed |
| WO-2001027081-A1 | 6-POSITION SUBSTITUTED INDOLINE, PRODUCTION AND USE THEREOF AS A MEDICAMENT | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170174625-A1 | PREPARATION METHOD OF NINTEDANIB | ACVR2B, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, NUDT1 | DRD4 3534/4885LMNA 2031/4885NPC1 3994/4885 |
| US-11261158-B2 | Synthesis of 2-indolinone derivatives | AZI2, AANAT, IDO1 | DRD4 553/4885LMNA 2714/4885NPC1 3408/4885 |
| US-20180215735-A1 | METHOD FOR PREPARING METHYL (Z)-3-[[4-[METHYL[2-(4-METHYL-1-PIPERAZINYL)ACETYL]AMINO]PHEHYL]AMINO]PHENYLMETHYLENE)-OXINDOLE-6-CARBOXYLATE (INTEDANIB, NINTEDANIB) | ALK, ACVR2B, ACVR1B | DRD4 2836/4885LMNA 1387/4885NPC1 4314/4885 |
| US-20200299275-A1 | SYNTHESIS OF 2-INDOLINONE DERIVATIVES | AZI2, AANAT, IDO1 | DRD4 553/4885LMNA 2714/4885NPC1 3408/4885 |
| US-20240051920-A1 | AN IMPROVED HIGHLY EFFICIENT PROCESS FOR THE PREPARATION OF NINTEDANIB AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | JAK1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, INMT | DRD4 2359/4885LMNA 3149/4885NPC1 1808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.