Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 3/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | GPR18 | Q14330 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28497091 | 0.88 | MDM4 (0.46) | MDM4TP53MDM2CDK5CDK5R1 | |
| SCHEMBL28501197 | 0.87 | MDM2 (0.52) | MDM4TP53MDM2SIRT2HTR6 | |
| SCHEMBL28492793 | 0.87 | MDM2 (0.62) | MDM4TP53MDM2SIRT2HTR6 | |
| SCHEMBL28503167 | 0.87 | TP53 (0.56) | MDM4TP53MDM2SIRT2HTR6 | |
| SCHEMBL28504165 | 0.85 | MDM2 (0.52) | MDM4TP53MDM2SIRT2HTR6 | |
| SCHEMBL28514431 | 0.85 | TP53 (0.52) | MDM4TP53MDM2SIRT2HTR6 | |
| SCHEMBL28508709 | 0.82 | HTR1A (0.52) | MDM4TP53MDM2SIRT2HTR6 | |
| SCHEMBL28506698 | 0.81 | MDM4 (0.48) | MDM4TP53MDM2SIRT2MAPK1 | |
| SCHEMBL28501215 | 0.80 | KDM4E (0.50) | MDM4TP53MDM2SIRT2HTR6 | |
| SCHEMBL28509176 | 0.80 | MDM4 (0.43) | MDM4TP53MDM2SIRT2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112174937-B | 3- (5-imidazolyl) indole compound and preparation method and application thereof | 南京农业大学 | 2022-06-03 | — | — | CN | disclosed |
| CN-112174937-A | 3- (5-imidazolyl) indole compound and preparation method and application thereof | 南京农业大学 | 2021-01-05 | — | — | CN | disclosed |