Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | DBH | P09172 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28501197 | 0.89 | MDM2 (0.52) | MDM4TP53MDM2SIRT2PDGFRB | |
| SCHEMBL28503167 | 0.89 | TP53 (0.56) | MDM4TP53MDM2SIRT2MAPK1 | |
| SCHEMBL28497040 | 0.87 | ALDH1A1 (0.49) | MDM4TP53MDM2SIRT2LMNA | |
| SCHEMBL28508702 | 0.87 | MDM4 (0.44) | MDM4TP53MDM2SIRT2DBH | |
| SCHEMBL28505021 | 0.84 | HTR1A (0.53) | MDM4TP53MDM2ROCK2ROCK1 | |
| SCHEMBL28492793 | 0.84 | MDM2 (0.62) | MDM4TP53MDM2SIRT2MAPK1 | |
| SCHEMBL28504165 | 0.82 | MDM2 (0.52) | MDM4TP53MDM2SIRT2LMNA | |
| SCHEMBL28514431 | 0.82 | TP53 (0.52) | MDM4TP53MDM2SIRT2MAPK1 | |
| SCHEMBL28505089 | 0.81 | MDM4 (0.49) | MDM4TP53MDM2SIRT2MAPK1 | |
| SCHEMBL28509176 | 0.81 | MDM4 (0.43) | MDM4TP53MDM2SIRT2NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112174937-B | 3- (5-imidazolyl) indole compound and preparation method and application thereof | 南京农业大学 | 2022-06-03 | — | — | CN | disclosed |
| CN-112174937-A | 3- (5-imidazolyl) indole compound and preparation method and application thereof | 南京农业大学 | 2021-01-05 | — | — | CN | disclosed |