Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.56 |
| ▸ | MDM4 | O15151 | 2/20 | 0.56 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28492793 | 0.92 | MDM2 (0.62) | TP53MDM2MDM4SIRT2HTT | |
| SCHEMBL28501197 | 0.90 | MDM2 (0.52) | TP53MDM2MDM4SIRT2HTT | |
| SCHEMBL28514431 | 0.90 | TP53 (0.52) | TP53MDM2MDM4SIRT2HTT | |
| SCHEMBL28504165 | 0.90 | MDM2 (0.52) | TP53MDM2MDM4SIRT2HTT | |
| SCHEMBL28501215 | 0.90 | KDM4E (0.50) | TP53MDM2MDM4SIRT2HTT | |
| SCHEMBL28497040 | 0.89 | ALDH1A1 (0.49) | TP53MDM2MDM4SIRT2HTT | |
| SCHEMBL28506698 | 0.89 | MDM4 (0.48) | TP53MDM2MDM4SIRT2MAPT | |
| SCHEMBL28508709 | 0.87 | HTR1A (0.52) | TP53MDM2MDM4SIRT2HTR1A | |
| SCHEMBL28505089 | 0.87 | MDM4 (0.49) | TP53MDM2MDM4SIRT2HTT | |
| SCHEMBL28508740 | 0.86 | TP53 (0.52) | TP53MDM2MDM4SIRT2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112174937-B | 3- (5-imidazolyl) indole compound and preparation method and application thereof | 南京农业大学 | 2022-06-03 | — | — | CN | disclosed |
| CN-112174937-A | 3- (5-imidazolyl) indole compound and preparation method and application thereof | 南京农业大学 | 2021-01-05 | — | — | CN | disclosed |