Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28524457 | 0.90 | HTT (0.62) | LMNAPOLBHTTRAB9ASMN1; SMN2 | |
| SCHEMBL12835472 | 0.85 | HTT (0.54) | LMNAPOLBHTTRAB9ASMN1; SMN2 | |
| SCHEMBL19420106 | 0.83 | HTT (0.72) | LMNAPOLBHTTRAB9ASMN1; SMN2 | |
| SCHEMBL10768094 | 0.83 | RAB9A (0.71) | LMNAPARP1PARP10POLBHTT | |
| SCHEMBL3917825 | 0.82 | EPHX2 (0.54) | LMNAPARP1PARP10POLBHTT | |
| SCHEMBL19711817 | 0.81 | NPC1 (0.66) | LMNAPOLBRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL15331088 | 0.80 | SMN1; SMN2 (0.55) | LMNAPARP1PARP10POLBHTT | |
| SCHEMBL13927087 | 0.79 | PARP1 (0.49) | LMNAPARP1PARP10POLBHTT | |
| SCHEMBL13927084 | 0.79 | PARP1 (0.49) | LMNAPARP1PARP10POLBHTT | |
| SCHEMBL28523948 | 0.78 | GPR55 (0.50) | LMNAPARP1PARP10HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114394940-B | Cyclopropyl-1, 1 diamide compound and preparation method and application thereof | 武汉工程大学 | 2024-01-16 | — | — | CN | disclosed |
| CN-114394940-A | Cyclopropyl-1, 1 diamide compound and preparation method and application thereof | 武汉工程大学 | 2022-04-26 | — | — | CN | disclosed |
| CN-108503650-B | Dioxane and quinazoline compound or medicinal salt or hydrate thereof and application of dioxane and quinazoline compound or medicinal salt or hydrate thereof as tyrosine kinase inhibitor | 北京赛特明强医药科技有限公司 | 2021-02-12 | — | — | CN | disclosed |