Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.72 |
| ▸ | RAB9A | P51151 | 2/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | GAA | P10253 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | FNTA | P49354 | 1/20 | 0.65 |
| ▸ | FNTB | P49356 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28524457 | 0.93 | HTT (0.62) | HTTRAB9ASMN1; SMN2KDM4EPOLB | |
| SCHEMBL7824367 | 0.84 | RAB9A (0.72) | HTTRAB9ASMN1; SMN2KDM4EPOLB | |
| SCHEMBL28508124 | 0.83 | LMNA (0.54) | HTTRAB9ASMN1; SMN2KDM4EPOLB | |
| SCHEMBL3917111 | 0.83 | RAB9A (1.00) | HTTRAB9ASMN1; SMN2KDM4EPOLB | |
| SCHEMBL7823539 | 0.83 | MAPT (1.00) | HTTRAB9ASMN1; SMN2KDM4EPOLB | |
| SCHEMBL12835472 | 0.82 | HTT (0.54) | HTTRAB9ASMN1; SMN2KDM4EPOLB | |
| SCHEMBL7814995 | 0.82 | HTT (0.71) | HTTRAB9ASMN1; SMN2KDM4EPOLB | |
| SCHEMBL12218175 | 0.80 | POLB (0.70) | HTTRAB9ASMN1; SMN2KDM4EPOLB | |
| SCHEMBL31335388 | 0.80 | RAB9A (0.72) | HTTRAB9ASMN1; SMN2KDM4EPOLB | |
| SCHEMBL7828785 | 0.80 | HTT (0.71) | HTTRAB9ASMN1; SMN2KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10195213-B2 | Chemical entities that kill senescent cells for use in treating age-related disease | UNITY BIOTECHNOLOGY, INC. (US) | 2019-02-05 | — | — | US | disclosed |
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | UNITY BIOTECHNOLOGY, INC. | 2017-10-05 | — | — | US | disclosed |
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | UNITY BIOTECHNOLOGY, INC. | 2017-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | TP53, NQO1, SHMT2 | HTT 356/4885RAB9A 1412/4885SMN1; SMN2 595/4885 |
| US-10195213-B2 | Chemical entities that kill senescent cells for use in treating age-related disease | TP53, CDKN1A, GLA | HTT 368/4885RAB9A 831/4885SMN1; SMN2 839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.