Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28511308 | 0.85 | SLC40A1 (0.47) | SLC40A1PIK3CBMAPTHTTPRKDC | |
| SCHEMBL28518634 | 0.77 | KDM4E (0.44) | PIK3CBKDM4E | |
| SCHEMBL2198567 | 0.76 | MAPT (0.53) | MAPTLMNANPSR1POLB | |
| SCHEMBL31239122 | 0.75 | DRD2 (0.42) | PIK3CBMAPTLMNAPRKDCPOLB | |
| SCHEMBL1275376 | 0.70 | PRKDC (0.58) | PIK3CBPRKDC | |
| SCHEMBL434090 | 0.69 | PRKDC (0.67) | TP53HSD17B10PIK3CBKDM4ELMNA | |
| SCHEMBL13403537 | 0.68 | PIK3CG (0.64) | PIK3CBKDM4EPRKDC | |
| SCHEMBL15125330 | 0.67 | DRD2 (0.35) | — | |
| SCHEMBL2197587 | 0.67 | KMO (0.51) | LMNAHTTPRKDC | |
| SCHEMBL31156589 | 0.66 | KDM4E (0.43) | MAPK1HSD17B10SLC40A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112300126-A | Heterocyclic DNA-PK inhibitors | 山东轩竹医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |