Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | BPTF | Q12830 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28515135 | 0.96 | ALDH1A1 (0.38) | PTGER4ALDH1A1SMN1; SMN2HTTTSHR | |
| SCHEMBL28906815 | 0.88 | PTGER4 (0.45) | PTGER4ALDH1A1SMN1; SMN2TSHRKMT2A | |
| SCHEMBL29200564 | 0.84 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2HTTTSHRAPOBEC3A | |
| SCHEMBL19437435 | 0.83 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2HTTTSHRAPOBEC3A | |
| SCHEMBL19437440 | 0.82 | MEN1 (0.43) | ALDH1A1SMN1; SMN2HTTTSHRAPOBEC3A | |
| SCHEMBL28517495 | 0.82 | MAPT (0.46) | PTGER4ALDH1A1SMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL28510943 | 0.79 | MAPT (0.46) | PTGER4ALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL22288356 | 0.78 | MAPK1 (0.39) | ALDH1A1SMN1; SMN2HTTTSHRAPOBEC3A | |
| SCHEMBL28751992 | 0.78 | MAPK1 (0.39) | ALDH1A1SMN1; SMN2HTTTSHRAPOBEC3A | |
| SCHEMBL22135029 | 0.78 | STING1 (0.44) | KMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112279835-B | Aromatic ring or aromatic heterocyclic imidazole compound, preparation method and pharmaceutical application thereof | 中国医学科学院药物研究所 | 2022-07-22 | — | — | CN | disclosed |
| CN-112279835-A | Aromatic ring or aromatic heterocyclic imidazole compound, preparation method and pharmaceutical application thereof | 中国医学科学院药物研究所 | 2021-01-29 | — | — | CN | disclosed |