Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | FPR3 | P25089 | 4/20 | 0.47 |
| ▸ | FPR2 | P25090 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 5/20 | 0.46 |
| ▸ | CA1 | P00915 | 5/20 | 0.46 |
| ▸ | CA2 | P00918 | 5/20 | 0.46 |
| ▸ | CA9 | Q16790 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18295921 | 0.92 | L3MBTL1 (0.55) | LMNAUSP2FPR3FPR2L3MBTL1 | |
| SCHEMBL14558708 | 0.86 | GAA (0.51) | LMNATDP1CA12CA1CA2 | |
| SCHEMBL24928322 | 0.84 | CA1 (0.44) | LMNATDP1CA12CA1CA2 | |
| SCHEMBL8795442 | 0.84 | TDP1 (0.47) | LMNATDP1CA12CA1CA2 | |
| SCHEMBL24762018 | 0.82 | TDP1 (0.51) | LMNAUSP2FPR3FPR2TDP1 | |
| SCHEMBL4969884 | 0.81 | CA12 (0.68) | FPR3FPR2TDP1CA12CA1 | |
| SCHEMBL7527120 | 0.81 | IDO1 (0.50) | LMNATDP1CA12CA1CA2 | |
| SCHEMBL10493712 | 0.80 | TDP1 (0.49) | LMNATDP1CA12CA1CA2 | |
| SCHEMBL2147505 | 0.80 | CA12 (0.69) | FPR3FPR2TDP1CA12CA1 | |
| SCHEMBL7894530 | 0.79 | MTNR1A (0.48) | TDP1CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |