SCHEMBL28512147

SCHEMBL28512147

Clc1ccc2c(c1)[CH]C=C2c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.40
SMN1; SMN2 Q16637 5/20 0.39
ALDH1A1 P00352 4/20 0.39
HPGD P15428 4/20 0.39
NPC1 O15118 3/20 0.39
RAB9A P51151 3/20 0.39
TP53 P04637 2/20 0.39
HSD17B10 Q99714 2/20 0.39
TSHR P16473 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
HSD11B1 P28845 1/20 0.37
S100A4 P26447 1/20 0.36
KMT2A Q03164 4/20 0.36
MEN1 O00255 3/20 0.36
RXFP1 Q9HBX9 1/20 0.36
GPR3 P46089 1/20 0.35
MAPT P10636 4/20 0.35
KDM4E B2RXH2 3/20 0.35
LMNA P02545 2/20 0.35
CYP19A1 P11511 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28025982 0.77 CYP1A2 (0.43) CYP1A2SMN1; SMN2ALDH1A1HPGDNPC1
SCHEMBL28025937 0.76 PTAFR (0.40) SMN1; SMN2NPC1RAB9ATP53TSHR
SCHEMBL5076754 0.76 ALDH1A1 (0.41) ALDH1A1HPGDHSD17B10MAPK1CYP2A6
SCHEMBL28515389 0.74 ESR2 (0.36) CYP1A2SMN1; SMN2ALDH1A1HPGDNPC1
SCHEMBL28303649 0.74 ALDH1A1 (0.39) ALDH1A1HPGDHSD17B10MAPK1CYP2A6
SCHEMBL28510021 0.73 PTGS2 (0.37) ALDH1A1HPGDNPC1RAB9ATP53
SCHEMBL27502471 0.73 ALDH1A1 (0.35) ALDH1A1HPGDHSD17B10KMT2ALMNA
SCHEMBL28025959 0.72 PTPRC (0.46) TSHRHSD11B1CYP2A6
SCHEMBL28025451 0.72 ESR2 (0.36) SMN1; SMN2ALDH1A1HPGDNPC1RAB9A
SCHEMBL28302275 0.70 ESR2 (0.35) SMN1; SMN2ALDH1A1NPC1RAB9AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108137729-B Catalysts for forming multimodal polymers 埃克森美孚化学专利公司 2021-02-05 CN disclosed