Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 11/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29029758 | 0.89 | PLA2G2A (0.49) | PLA2G2ALMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL29029791 | 0.86 | CA5A (0.37) | PLA2G2ALMNAKMT2APTGS2MAPK1 | |
| SCHEMBL27844984 | 0.86 | PLA2G2A (0.49) | PLA2G2A | |
| SCHEMBL818097 | 0.83 | PLA2G2A (0.65) | PLA2G2A | |
| SCHEMBL6691708 | 0.81 | LMNA (0.48) | PLA2G2ALMNAMEN1XBP1KMT2A | |
| SCHEMBL29029775 | 0.79 | PARP1 (0.41) | PLA2G2AMEN1KMT2APTGS2ALDH1A1 | |
| SCHEMBL29029784 | 0.79 | PLA2G2A (0.40) | PLA2G2APTGS2 | |
| SCHEMBL8080891 | 0.79 | PLA2G2A (0.74) | PLA2G2A | |
| SCHEMBL29029761 | 0.79 | AURKA (0.38) | PLA2G2AKMT2APTGS2MAPK1ALDH1A1 | |
| SCHEMBL29029767 | 0.78 | PLA2G2A (0.50) | PLA2G2APTGS2ALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116585306-A | PLA2 inhibitors for immediate treatment of hymenoptera toxicity and other conditions due to histamine release | 奥菲瑞克斯股份有限公司 | 2023-08-15 | — | — | CN | disclosed |
| CN-109562098-B | PLA2 inhibitors for immediate treatment of hymenoptera toxicity and other conditions due to histamine release | 奥菲瑞克斯股份有限公司 | 2023-04-21 | — | — | CN | disclosed |
| CN-107249578-B | Method for treating envenomation and related pharmaceutical composition, system and kit | 奥菲瑞克斯股份有限公司 | 2021-01-26 | — | — | CN | disclosed |