SCHEMBL2851266

SCHEMBL2851266

C=C(COc1cc(C)c(-c2ccccc2)nc1Cl)C(=O)OCC

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.42
MAPT P10636 3/20 0.42
LMNA P02545 2/20 0.42
MAPK1 P28482 1/20 0.42
ATM Q13315 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
XPO1 O14980 1/20 0.41
KMT2A Q03164 2/20 0.39
HPGDS O60760 1/20 0.39
KDM4E B2RXH2 2/20 0.39
HTT P42858 1/20 0.39
ADORA3 P0DMS8 1/20 0.39
MPO P05164 1/20 0.39
DHODH Q02127 2/20 0.38
HPGD P15428 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2850939 0.90 MPO (0.41) ALDH1A1LMNAMAPK1ATMKMT2A
SCHEMBL2853200 0.82 XPO1 (0.42) ALDH1A1MAPTLMNAMAPK1ATM
SCHEMBL2853209 0.78 L3MBTL1 (0.38) ALDH1A1LMNAKMT2AKDM4EHTT
SCHEMBL2851268 0.76 CASP1 (0.58) ALDH1A1MAPTLMNAMAPK1ATM
SCHEMBL18799216 0.73 TSHR (0.47) ALDH1A1MAPTLMNAMAPK1SMN1; SMN2
SCHEMBL2853192 0.72 XPO1 (0.35) ALDH1A1MAPTLMNAMAPK1XPO1
SCHEMBL6613605 0.71 ALDH1A1 (0.53) ALDH1A1MAPTSMN1; SMN2KMT2AKDM4E
SCHEMBL2859252 0.70 MAPT (0.41) MAPTMAPK1SMN1; SMN2HTTL3MBTL1
SCHEMBL2853107 0.70 ALDH1A1 (0.39) ALDH1A1MAPTKMT2AKDM4EMPO
SCHEMBL2849135 0.70 CASP1 (0.56) ALDH1A1MAPTLMNAMAPK1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1924558-B1 AN ANTIMALARIAL BAYLIS-HILLMAN ADDUCTS AND A PROCESS FOR THE PREPARATION THEREOF COUNCIL SCIENT IND RES (IN) 2010-01-13 EP claimed
EP-1924558-A1 AN ANTIMALARIAL BAYLIS-HILLMAN ADDUCTS AND A PROCESS FOR THE PREPARATION THEREOF COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2008-05-28 EP claimed
WO-2007032016-A1 AN ANTIMALARIAL BAYLIS-HILLMAN ADDUCTS AND A PROCESS FOR THE PREPARATION THEREOF COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2007-03-22 WO claimed
EP-1924558-B1 AN ANTIMALARIAL BAYLIS-HILLMAN ADDUCTS AND A PROCESS FOR THE PREPARATION THEREOF COUNCIL SCIENT IND RES (IN) 2010-01-13 EP disclosed
EP-1924558-A1 AN ANTIMALARIAL BAYLIS-HILLMAN ADDUCTS AND A PROCESS FOR THE PREPARATION THEREOF COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2008-05-28 EP disclosed
WO-2007032016-A1 AN ANTIMALARIAL BAYLIS-HILLMAN ADDUCTS AND A PROCESS FOR THE PREPARATION THEREOF COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2007-03-22 WO disclosed