Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | TOP1 | P11387 | 2/20 | 0.41 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28514742 | 1.00 | MAPT (0.50) | MAPTKDM4EMAPK1HTTNPSR1 | |
| SCHEMBL28510819 | 0.89 | RAB9A (0.46) | MAPTKDM4EL3MBTL1ADORA2AADORA1 | |
| SCHEMBL28549182 | 0.88 | HSD17B1 (0.44) | MAPTKDM4ENPSR1HSD17B1HSD17B2 | |
| SCHEMBL28504247 | 0.82 | NPC1 (0.51) | MAPTKDM4ENPSR1L3MBTL1ALDH1A3 | |
| SCHEMBL28517001 | 0.82 | ALDH1A1 (0.48) | MAPTKDM4EMAPK1ADORA2AADORA1 | |
| SCHEMBL28501588 | 0.82 | NPC1 (0.51) | MAPTKDM4EL3MBTL1ALDH1A3ADORA2A | |
| SCHEMBL28906122 | 0.82 | NPC1 (0.51) | MAPTKDM4EL3MBTL1ALDH1A3ADORA2A | |
| SCHEMBL28506811 | 0.82 | ALDH1A1 (0.48) | MAPTKDM4EMAPK1ADORA2AADORA1 | |
| SCHEMBL28506806 | 0.82 | NPC1 (0.51) | MAPTKDM4ENPSR1L3MBTL1ALDH1A3 | |
| SCHEMBL28502053 | 0.81 | KIF11 (0.53) | MAPTTOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112159364-B | Synthetic method of isothiazole derivative | 温州大学 | 2022-06-24 | — | — | CN | disclosed |
| CN-112159364-A | Synthetic method of isothiazole derivative | 温州大学 | 2021-01-01 | — | — | CN | disclosed |