Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.55 |
| ▸ | NEK1 | Q96PY6 | 5/20 | 0.51 |
| ▸ | SGK1 | O00141 | 1/20 | 0.51 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | FRK | P42685 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.42 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.42 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.42 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8941622 | 0.87 | AXL (0.71) | AXLSGK1CAMKK2JAK2PRKD3 | |
| SCHEMBL18797714 | 0.74 | SLC40A1 (0.46) | AXLNEK1KDRFLT3 | |
| SCHEMBL9936933 | 0.73 | AXL (0.63) | AXLJAK2MAP4K4LCKFYN | |
| SCHEMBL858763 | 0.72 | ALDH1A1 (0.43) | AXLNEK1SGK1CAMKK2JAK2 | |
| SCHEMBL8940901 | 0.72 | AXL (0.70) | AXLSGK1CAMKK2JAK2PRKD3 | |
| SCHEMBL8940681 | 0.71 | MAP3K11 (0.68) | AXLSGK1CAMKK2JAK2PRKD3 | |
| SCHEMBL28502357 | 0.71 | JAK2 (0.53) | AXLJAK2CLK2CLK4CLK1 | |
| SCHEMBL17437990 | 0.70 | ROCK2 (0.58) | — | |
| SCHEMBL8940832 | 0.70 | JAK2 (0.56) | AXLSGK1CAMKK2JAK2PRKD3 | |
| SCHEMBL22574155 | 0.70 | ERN1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |