Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 1.00 |
| ▸ | GAA | P10253 | 4/20 | 0.85 |
| ▸ | POLB | P06746 | 1/20 | 0.85 |
| ▸ | GFER | P55789 | 2/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.74 |
| ▸ | HPGD | P15428 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 8/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.62 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.62 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28517560 | 0.92 | MAPT (1.00) | MAPTGAAPOLBGFERALDH1A1 | |
| SCHEMBL28515982 | 0.88 | MAPT (0.79) | MAPTGAAPOLBGFERALDH1A1 | |
| SCHEMBL8298517 | 0.87 | NOX4 (0.79) | MAPTGAAPOLBGFERALDH1A1 | |
| SCHEMBL28510033 | 0.87 | NOX4 (0.79) | MAPTGAAPOLBGFERALDH1A1 | |
| SCHEMBL28906620 | 0.85 | MAPT (0.73) | MAPTGAAPOLBGFERALDH1A1 | |
| SCHEMBL28512241 | 0.83 | MAPT (0.84) | MAPTGAAPOLBGFERALDH1A1 | |
| SCHEMBL28528683 | 0.83 | MAPT (0.80) | MAPTGAAPOLBGFERALDH1A1 | |
| SCHEMBL8298558 | 0.83 | MAPT (0.85) | MAPTGAAPOLBGFERALDH1A1 | |
| SCHEMBL28510030 | 0.82 | LMNA (0.76) | MAPTGAAPOLBGFERALDH1A1 | |
| SCHEMBL28513870 | 0.82 | GAA (0.82) | MAPTGAAPOLBGFERALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112079744-A | Aromatic acylhydrazone derivatives and application thereof as NA (adenosine) inhibitor | 湖南大学 | 2020-12-15 | — | — | CN | claimed |
| CN-112079744-B | Aromatic acylhydrazone derivatives and application thereof as NA (adenosine) inhibitor | 湖南大学 | 2021-07-30 | — | — | CN | disclosed |
| CN-112079744-A | Aromatic acylhydrazone derivatives and application thereof as NA (adenosine) inhibitor | 湖南大学 | 2020-12-15 | — | — | CN | disclosed |