Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.50 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.37 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28523802 | 0.91 | RIPK1 (0.48) | RIPK1PDE5AJAK2NTRK1GPR119 | |
| SCHEMBL31479247 | 0.91 | RIPK1 (0.50) | RIPK1PDE5AJAK2NTRK1GPR119 | |
| SCHEMBL21093668 | 0.91 | RIPK1 (0.50) | RIPK1PDE5AJAK2NTRK1GPR119 | |
| SCHEMBL28518933 | 0.88 | FFAR2 (0.41) | RIPK1KDM4EABCB1FFAR2 | |
| SCHEMBL21094108 | 0.87 | GPR119 (0.46) | GPR119MAOBABCB1MAOA | |
| SCHEMBL21094095 | 0.86 | FFAR2 (0.46) | RIPK1PDE5AMAOBABCB1MAOA | |
| SCHEMBL2584143 | 0.86 | RIPK1 (0.46) | RIPK1PDE5AJAK2NTRK1GPR119 | |
| SCHEMBL21094091 | 0.86 | FFAR2 (0.44) | RIPK1ABCB1FFAR2 | |
| SCHEMBL28511990 | 0.85 | ABCB1 (0.49) | RIPK1GPR119KDM4EPKMABCB1 | |
| SCHEMBL21094369 | 0.85 | RIPK1 (0.45) | RIPK1PDE5AJAK2NTRK1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109476639-B | Pyrrolidine derivatives | 橘生药品工业股份有限公司 | 2021-02-26 | — | — | CN | disclosed |